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Check this out! I had the same problem as you, i have an account with every sportsbook/poker/casino website. After seeing which are popular and which are not, i decided to create a website to guide USA people like ourselves to appropriate sportsbooks that will payout and take real money deposit from players from USA, since the law to ban online gamling transactons in 2006. was passed.
Feel free sanding me a shout.
Here is the website http://www.opensportsbookusa.com, or http://www.usagambler.net
I would suggest www.sportsbook.com, mostly because their lines are all interconnected with the real life sportsbooks in Reno, which are mostly all run by Cal-Neva. And all those lines are set by a website www.covers.com .
If you want to bet NFL, you can get the lines every morning at 6am on Tuesday (not sure what time zone) at www.covers.com
I highly suggest that if you are ever in doubt about whom to bet for, go for the more experienced team. Also remember regions, Midwest is more strategy, South and west are power, and East Coast is a combo of both. Generalization sure, but a fairly accurate one.